Tangential Flow Filtration (TFF) is an efficient separation and purification method commonly used during the production process of biological and blood products and vaccines which have a molecular weight of 1-1000kda. It is essential to choose the proper cassette material to ensure efficient process downstream.

In tangential flow filtration, flow is tangential to the membrane. Due to membrane porosity and trans-membrane pressure (TMP), a partial flow crosses the membrane with the remaining flow left in the recycling system. As this occurs, tangential force flushes the membrane, making it hard to form the gel on the surface of the membrane. This prevents the membrane from blocking thus keeping flow rate stable.

Typical Applications

• Concentration, Clarification and Dialysis of Antibiotics, Nucleic Acids,Proteins, and Other Bio-molecular Products
• Buffering Exchange
• Clarification before Chromatography
• Endotoxin Removal
• Product Recovery, Washing and Clarification of Gel-suspended Liquids and Cell/Virus Culture Media